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Thus, this mechanism, which avoids excessive nutrients, achieves metabolically active organs with a gain in insulin sensitivity and weight loss, providing long-lasting effects, unlike drugs, that act only in a weight-dependent manner (23)

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During the titration period, doses of metformin were increased up to 2,000 mg/day

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You may experience fatigue or lethargy, among other symptoms, if you have a B12 deficiency